The MR250 uses a power-jet 34mm carb (I believe it's the first Keihin to use a power jet, but I could be wrong). The pilot and throttle valve specs may be helpful, but I don't think anything else will be close enough to be useful to you.
If your Mikuni was used when you bought it, I would assume
absolutely nothing about it. I still get pissed off thinking about the months I spent chasing my tail with my 28mm Keihin, only to find some clown had drilled out the needle jet (the result was a ridiculously over-rich condition that no jetting change seemed to affect much - sound familiar?). Also, the throttle valve can have a HUGE impact on throttle response, although changing the needle diameter can have a similar effect.
Here's a posting redrocket190 made here in April 2006 regarding a '79 CR250; it seems pretty much on-point for your needs:
Mikuni VM36 Round slide
Air screw 1.5-2.0 turns out
Pilot 35
Air 200
Slide 2.5
Needle jet 159-P8
Needle 6FJ6
Clip #2-#3 from the top
Main 350
This is ball-park for Southern California. You would need fine-tune the air screw, needle clip and main to suit. http://www.sudco.com has full charts on alternative needles if you need them. Sam Alexander at http://www.jastco.com also has some ideas on radical set-up for these carbs. You will also need to grind down the bell of the carb to get it to fit between the rubber boots on the CR250R. The Mikuni is longer than the stock Keihin. I have a picture...Just for what it's worth... a 36mm CR250M ('77?) Keihin carb worked very well in my CR125M. It should have been a disaster on that small of a piston-port motor, but once I got it dialed in - even though I knew jack about jetting back then - it worked cleanly for years. I can only imagine how well it would have worked on a 250. If all else fails with your Mikuni, these carbs come up on eBay from time to time, and the stock jetting should be very close.
Ray